Vitamin K Dependent Clotting Factors Mnemonic

Factors ii vii ix and x require calcium factor iv and phospholipid pl for activation.

Vitamin k dependent clotting factors mnemonic. Fat soluble vitamin synthesized by intestinal bacteria. These are vitamin k dependent coagulation factors and affected most by liver disease and warfarin. Mnemonic for clotting factors. Cystic fibrosis pancreatic insufficiency crohn s malnourishment or long term antibiotic use.

Clotting factors are usually inactive but once there is an injury to the wall of the blood vessel they get activated. Typically seen with fat malabsorption e g. They are factors 2 7 9 10 the story behind the picture mnemonic. The function of clotting factors is to trigger the formation of a blood clot and stabilize it for as long as necessary.

To remember the vitamin k dependent factors try to memorize this picture. F reshers p arty t. Without carboxylation clotting factors proteins are not activated and clotting cascade does not occur. The child grew up got 10 upon 10 marks.

Vitamin k is activated by the enzyme epoxide reductase to its reduced form which acts as a cofactor for gamma carboxylation of glutamic acid residues on blood clotting proteins. Therefore vitamin k plays an important role in coagulation formation of blood clots as there are a number of such vitamin k dependent. Warfarin 4 hydroxycoumarin inhibits the synthesis of vitamin k dependent coagulation factors including factors ii vii ix and x as well as proteins c and s. It is commonly used for prevention and treatment of vte prevention of stroke in atrial fibrillation anticoagulation for mechanical prosthetic heart valves and myocardial infarction prevention in coronary artery disease.

Factors 10 9 7 2 w. Summary vitamin k is a fat soluble vitamin synthesized by intestinal bacteria. Vitamin k is required for carboxylation of terminal ends of coagulation proteins. Prothrombin time factors x ix vii ii are vitamin k dependent.

Vitamin k is an essential cofactor in the activation of certain proteins within your body 1. Without the activation step certain biochemical reactions cannot be completed. Extrinsic pathway is affected and hence pt inr is elevated. In year 2k 2000 factor 2 is k dependant a pregnant lady after carrying her child for 9 months caring all 7 days a week gave birth to a child.

Von hippel lindau mnemonic vhl 3 letters therefore chromosome 3 deletion bilateral renal cell carcinomas v vhl gene h hemangioblastomas l lots of catecholamines i e. Normal pt is 12 16 seconds. All of these clotting factors both pro coagulant and anticoagulant are vitamin k dependent. Warfarin acts on extrinsic pathway prothrombin time used to check it.

Clotting factors are therefore known as procoagulants. Intrinsic pathway is activated by subendothelial collagen. A vitamin k deficiency will predispose you to bleeding and blocking vitamin k prevents inappropriate clotting. Warfarin inhibits the cyclic interconversion of vitamin k to a.

Vitamin k dependent clotting factors mnemonic 1972 factors x ix vii ii also proteins c and s.