Vitamin K Dependent Clotting Factors Liver

A vitamin k deficiency will predispose you to bleeding and blocking vitamin k prevents inappropriate clotting.

Vitamin k dependent clotting factors liver. Proteins c and s whereas other parameters remain normal. In the molecular structure of these coagulation factors there are different numbers of γ carboxyglutamic acid γ gla residues which locate in the n terminal of their own genes in physiological conditions these glutamate residues have γ carboxylation. The extent of coagulation abnormalities depends upon the degree of disturbed liver function. Warfarin 4 hydroxycoumarin inhibits the synthesis of vitamin k dependent coagulation factors including factors ii vii ix and x as well as proteins c and s.

With the participation of vitamin k vitamin k dependent coagulation factors ii vii ix and x synthesize in the liver. We aimed to assess whether vitamin k administration increases the levels of the vitamin k dependent factor vii fvii protein c and protein s in patients with different stages of liver dysfunction. Vitamin k is an essential cofactor in the activation of certain proteins within your body 1. Factors vii ix and x.

Without the activation step certain biochemical reactions cannot be completed. Eighty nine patients were recruited into four groups.