Vitamin K Dependent Factors Mnemonic
Warfarin epoxido reductase inhibition see mindmap.
Vitamin k dependent factors mnemonic. Vitamin e toxicity inhibits vitamin k dependent factors. Factors 10 9 7 2 w. Also anticoagulation proteins c s and z as well as osteocalcin and the matrix gla protein depend on vitamin k. Vitamin k dependant clotting factors.
Mnemonic for vitamin k dependent cofactors keyword suggestions. Bleeding time because platelets are not affected. Factor seven ten two nine s protein c protein see below for mnemonic suggestions create your own mnemonic for vitamin k dependent cofactors or view other mnemonic topics. Vitamin k deficiency presents.
Vitamin k is important in the steps involving protein factor ii vii ix and x 1. Intrinsic pathway is activated by subendothelial collagen. Summary vitamin k deficiency typically presents with bleeding or hemorrhage. It is commonly used for prevention and treatment of vte prevention of stroke in atrial fibrillation anticoagulation for mechanical prosthetic heart valves and myocardial infarction prevention in coronary artery disease.
These are also vitamin k dependent and warfarin vitamin k inhibitor given may initially have paradoxical pro coagulant effect due to inhibition of protein c and s. Glutamate carboxilation by vitamin k. Factors 12 to 8 are involved in intrinsic pathway excluding factor 10 which is a part of common pathway. To remember the vitamin k dependent factors try to memorize this picture.
Specifically crohn s disease cystic fibrosis and other causes of pancreatic insufficiency can lead to poor absorption of this fat soluble vitamin. Prothrombin alone needs vitamin k to modify 10 different regions within the protein for functionality. Insufficient production by gut flora is of particular concern in newborns. Vitamin k dependent proteins include factors ii vii ix x proteins c and s warfarin coumadin inhibits epoxide reductase blocking vitamin k mediated gamma carboxylation find vitamin k biochemistry and other vitamins among pixorize s visual mnemonics for the usmle step 1 and nbme shelf exams.
Vitamin k antagonist. Sep 8 2017 mnemonic for vitamin k dependent clotting factors 2 plus 7 is 9 not 10. Warfarin acts on extrinsic pathway prothrombin time used to check it. If you know this the other one is the other one.
Prothrombin time factors x ix vii ii are vitamin k dependent. 2 7 9 10 c s. Warfarin 4 hydroxycoumarin inhibits the synthesis of vitamin k dependent coagulation factors including factors ii vii ix and x as well as proteins c and s. The child grew up got 10 upon 10 marks.
Factor ii is alternatively named prothrombin. Extrinsic pathway is activated by tissue thromboplastin.